Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease

Therapeutic effects of adipose-derived mesenchymal stem cells combined with glymphatic system activation in prion disease

Blog Article

Abstract There is currently no effective therapy for prion diseases.The glymphatic system is an throwing stars organized system of perivascular spaces that facilitates the removal of metabolic waste from the brain.This study demonstrates the therapeutic potential of a combination therapy of adipose-derived mesenchymal stem cells (AdMSCs) and a glymphatic system-activated drug, clonidine, against prion disease.The therapy has the potential to clear PrPSc accumulation, grip ameliorate astrocytosis, and prolong the survival time of ME7-infected mice.